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Am J Transl Res 2011;3(2):149-158
Review Article
Matrix metalloproteinase activity and glycosaminoglycans in chronic
venous disease: the linkage among cell biology, pathology and
translational research
Ferdinando Mannello, Joseph D. Raffetto
Department of Biomolecular Sciences, Section of Clinical Biochemistry, Unit of Cell Biology, University “Carlo Bo”,
Urbino, Italy; Vascular Surgery Division, VA Boston Healthcare System, West Roxbury, MA; 3Harvard Medical
School, Brigham and Women’s Hospital, Boston, MA, USA
Received November 15, 2010; Accepted November 22, 2010; Epub November 23, 2010; Published January 1,
2011
Abstract: Primary chronic venous disease (CVD) is an inflammatory pathology involving an erratic structural
remodeling in the venous well leading to vascular incompetence and the development of varicose vein,
characterized by altered collagen and elastin content. In the early steps of varicose vein formation is crucial the
role of MMP/TIMP balance, implicated in both ECM and vascular degradation during inflammation processes in
early and late stages of venous diseases. Although several pharmacological and surgical strategies are being
utilized in the management of varicose vein and CVD with variable success and recurrence rate, inhibition of MMP
through glycosaminoglycans may represent a novel therapeutic intervention to limit the progression of varicose
vein to CVD and leg ulceration, suggesting possible opportunity to prevent future morbidity and enhancing clinical
benefits and quality of life. (AJTR1011003)
Keywords: Matrix metalloproteinase, glycosaminoglycan, chronic venous disease, inflammation, venous ulcer,
leukocyte, fibroblast, dermatan sulphate, varicose vein, tissue inhibitor of MMP
Full Text PDF
Address all correspondence to:
Ferdinando Mannello, PhD, Department of Biomolecular Sciences, Clinical Biochemistry Section, Unit of Cell
Biology, University “Carlo Bo”, Via O. Ubaldini 7, 61029 Urbino (PU), Italy. Tel: 0722 351479, Fax: 0722 322370, E-
mail: ferdinando.mannello@uniurb.it
Review Article
Matrix metalloproteinase activity and glycosaminoglycans in chronic
venous disease: the linkage among cell biology, pathology and
translational research
Ferdinando Mannello, Joseph D. Raffetto
Department of Biomolecular Sciences, Section of Clinical Biochemistry, Unit of Cell Biology, University “Carlo Bo”,
Urbino, Italy; Vascular Surgery Division, VA Boston Healthcare System, West Roxbury, MA; 3Harvard Medical
School, Brigham and Women’s Hospital, Boston, MA, USA
Received November 15, 2010; Accepted November 22, 2010; Epub November 23, 2010; Published January 1,
2011
Abstract: Primary chronic venous disease (CVD) is an inflammatory pathology involving an erratic structural
remodeling in the venous well leading to vascular incompetence and the development of varicose vein,
characterized by altered collagen and elastin content. In the early steps of varicose vein formation is crucial the
role of MMP/TIMP balance, implicated in both ECM and vascular degradation during inflammation processes in
early and late stages of venous diseases. Although several pharmacological and surgical strategies are being
utilized in the management of varicose vein and CVD with variable success and recurrence rate, inhibition of MMP
through glycosaminoglycans may represent a novel therapeutic intervention to limit the progression of varicose
vein to CVD and leg ulceration, suggesting possible opportunity to prevent future morbidity and enhancing clinical
benefits and quality of life. (AJTR1011003)
Keywords: Matrix metalloproteinase, glycosaminoglycan, chronic venous disease, inflammation, venous ulcer,
leukocyte, fibroblast, dermatan sulphate, varicose vein, tissue inhibitor of MMP
Full Text PDF
Address all correspondence to:
Ferdinando Mannello, PhD, Department of Biomolecular Sciences, Clinical Biochemistry Section, Unit of Cell
Biology, University “Carlo Bo”, Via O. Ubaldini 7, 61029 Urbino (PU), Italy. Tel: 0722 351479, Fax: 0722 322370, E-
mail: ferdinando.mannello@uniurb.it