| AJTR Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Am J Transl Res 2009;1(3):312-325
Review Article
CAAX-box protein, prenylation process and carcinogenesis
Juehua Gao, Jie Liao, Guang-Yu Yang
Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue,
Chicago, Illinois, USA
Received May 17, 2009; accepted May 21, 2009; available online May 25, 2009
Abstract: CAAX proteins are widely involved in global cellular functions such as proliferation, differentiation, and
carcinogenesis. As an important modulation of biological activity, signal transduction via protein prenylation is a
crucial step for most CAAX protein functions, particularly for anchoring these CAAX proteins to cellular membrane
system. With the better understanding of the molecular mechanisms of signal transduction and intracellular
messaging in this process, CAAX protein prenylation may be of particular importance for elucidating the biologic
events in carcinogenesis and provide potential approaches of selectively blocking the downstream signal
cascade that is important for carcinogenesis. Here, we mainly focus on the prenylation process of the clinically
important CAAX box proteins, and their potential as the biomarker or preventive/therapeutic targets in
carcinogenesis.(AJTR905003).
Key words: CAAX-box protein, prenylation, carcinogenesis, biomarker, signal transduction
Full Text PDF
Address all correspondence to:
Guang-Yu Yang, M.D., Ph.D.
Department of Pathology, Northwestern University, Feinberg School of Medicine,
303 East Chicago Avenue, Chicago, IL 60611
Fax: 312-503-0647
E-mail: g-yang@northwestern.edu
Review Article
CAAX-box protein, prenylation process and carcinogenesis
Juehua Gao, Jie Liao, Guang-Yu Yang
Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue,
Chicago, Illinois, USA
Received May 17, 2009; accepted May 21, 2009; available online May 25, 2009
Abstract: CAAX proteins are widely involved in global cellular functions such as proliferation, differentiation, and
carcinogenesis. As an important modulation of biological activity, signal transduction via protein prenylation is a
crucial step for most CAAX protein functions, particularly for anchoring these CAAX proteins to cellular membrane
system. With the better understanding of the molecular mechanisms of signal transduction and intracellular
messaging in this process, CAAX protein prenylation may be of particular importance for elucidating the biologic
events in carcinogenesis and provide potential approaches of selectively blocking the downstream signal
cascade that is important for carcinogenesis. Here, we mainly focus on the prenylation process of the clinically
important CAAX box proteins, and their potential as the biomarker or preventive/therapeutic targets in
carcinogenesis.(AJTR905003).
Key words: CAAX-box protein, prenylation, carcinogenesis, biomarker, signal transduction
Full Text PDF
Address all correspondence to:
Guang-Yu Yang, M.D., Ph.D.
Department of Pathology, Northwestern University, Feinberg School of Medicine,
303 East Chicago Avenue, Chicago, IL 60611
Fax: 312-503-0647
E-mail: g-yang@northwestern.edu
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