AJTR Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Am J Transl Res 2009;1(3):211-220

Review Article
Integrin signaling aberrations in prostate cancer

Hira Lal Goel, Naved Alam, Isaac N.S. Johnson & Lucia R. Languino

Department of Cancer Biology, Prostate Cancer Discovery and Development Program, Cancer Center,
University of Massachusetts Medical School, Worcester, MA 01605

Received April 18, 2009; accepted April 20, 2009; available online April 25, 2009

Abstract: Integrins are cell surface receptors for extracellular matrix proteins and play a key role in cell survival,
proliferation, migration and gene expression.  Integrin signaling has been shown to be deregulated in several
types of cancer, including prostate cancer.  This review is focused on integrin signaling pathways known to be
deregulated in prostate cancer and to promote prostate cancer progression. (AJTR904003).

Key words: Focal adhesion kinase, PTEN, PI 3-kinase/AKT, Ras/Raf/MAP kinase, cdc2.

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Address all correspondence to:
Lucia R. Languino, PhD
Department of Cancer Biology
Prostate Cancer Discovery and Development Program, Cancer Center,
University of Massachusetts Medical School, Worcester, MA 01605
Email:
lucia.languino@umassmed.edu