| AJTR Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Am J Transl Res 1(3):221-234;2009
Review Article
Genetics of coronary artery disease: focus on genome-wide
association studies
Linnea M. Baudhuin
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
Received February 27, 2009; accepted March 5, 2009; available online March 5, 2009
Abstract: With the advent of the genome-wide association (GWA) study, a promising new avenue for identifying
genetic markers for complex diseases like coronary artery disease (CAD) has been opened. This avenue,
however, is not without challenges and limitations, including the need for carefully designed and executed
studies and the risk of false positive associations. Nonetheless, new markers have been identified through such
studies that could potentially revolutionize the ways that individuals with CAD are identified and
managed.(AJTR902004).
Key Words: atherosclerosis, coronary artery disease, genetics, genome wide association, genomics, myocardial
infarction
Full Text PDF
Address all correspondence to:
Linnea M. Baudhuin, Ph.D.,
Department of Laboratory Medicine and Pathology
Mayo Clinic, 200 First St SW
Rochester, MN 55905
Tel: (507) 284-2511, Fax: (507) 266 4176
E-mail: baudhuin.linnea@mayo.edu
Review Article
Genetics of coronary artery disease: focus on genome-wide
association studies
Linnea M. Baudhuin
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
Received February 27, 2009; accepted March 5, 2009; available online March 5, 2009
Abstract: With the advent of the genome-wide association (GWA) study, a promising new avenue for identifying
genetic markers for complex diseases like coronary artery disease (CAD) has been opened. This avenue,
however, is not without challenges and limitations, including the need for carefully designed and executed
studies and the risk of false positive associations. Nonetheless, new markers have been identified through such
studies that could potentially revolutionize the ways that individuals with CAD are identified and
managed.(AJTR902004).
Key Words: atherosclerosis, coronary artery disease, genetics, genome wide association, genomics, myocardial
infarction
Full Text PDF
Address all correspondence to:
Linnea M. Baudhuin, Ph.D.,
Department of Laboratory Medicine and Pathology
Mayo Clinic, 200 First St SW
Rochester, MN 55905
Tel: (507) 284-2511, Fax: (507) 266 4176
E-mail: baudhuin.linnea@mayo.edu
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