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Am J Transl Res 1(1):44-54;2009
Review Article
Molecular Epidemiology of Genetic Susceptibility to Gastric Cancer:
Focus on Single Nucleotide Polymorphisms in Gastric Carcinogenesis
Ming Yin, Zhibin Hu, Dongfeng Tan, Jaffer A. Ajani, Qingyi Wei
Departments of Epidemiology, Pathology, and Gastrointestinal Medical Oncology, The University of Texas M. D.
Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA
Received December 10, 2008; accepted November, 2008; available online January 1, 2009
Abstract: Gastric cancer is a disease of gene-environment interactions, as suggested by the varying geographic
patterns of its incidence. Even in areas with high rates of Helicobacter pylori infection, only a small proportion of
infected individuals develop gastric cancer. Genetic susceptibility to gastric cancer can be investigated by
common genetic variants, such as single nucleotide polymorphisms (SNPs), in various genes that regulate
multiple biological pathways. The susceptibility to gastric carcinogenesis has a substantial influence on the
population attributable risk by modulating the effects of environmental risk factors. Despite recent progress in the
field of the molecular epidemiology of cancer, a re-evaluation of gastric cancer susceptibility and potentially
functional SNPs in candidate genes is necessary, given the inconsistency of previous reported studies. This
review focuses on genetic variants that contribute to the etiology of gastric cancer, particularly those SNPs
involved in inflammatory response, metabolism of chemical carcinogens, DNA repair, and tumor suppression. In
the future, well-designed large multicenter population-based studies will be needed to validate current findings
and provide the rationale for identifying at-risk subpopulations for primary prevention of gastric cancer.
(AJTR812001).
Key Words: Gastric cancer, meta-analysis, genetic polymorphism
Full Text PDF
Address all correspondence to:
Qingyi Wei, MD, PhD
Department of Epidemiology
The University of Texas M. D. Anderson Cancer Center, Unit 1365
1515 Holcombe Blvd, Houston, TX 77030
USA
Phone: 713-792-3020; Fax: 713-563-0999;
E-mail: qwei@mdanderson.org
Review Article
Molecular Epidemiology of Genetic Susceptibility to Gastric Cancer:
Focus on Single Nucleotide Polymorphisms in Gastric Carcinogenesis
Ming Yin, Zhibin Hu, Dongfeng Tan, Jaffer A. Ajani, Qingyi Wei
Departments of Epidemiology, Pathology, and Gastrointestinal Medical Oncology, The University of Texas M. D.
Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA
Received December 10, 2008; accepted November, 2008; available online January 1, 2009
Abstract: Gastric cancer is a disease of gene-environment interactions, as suggested by the varying geographic
patterns of its incidence. Even in areas with high rates of Helicobacter pylori infection, only a small proportion of
infected individuals develop gastric cancer. Genetic susceptibility to gastric cancer can be investigated by
common genetic variants, such as single nucleotide polymorphisms (SNPs), in various genes that regulate
multiple biological pathways. The susceptibility to gastric carcinogenesis has a substantial influence on the
population attributable risk by modulating the effects of environmental risk factors. Despite recent progress in the
field of the molecular epidemiology of cancer, a re-evaluation of gastric cancer susceptibility and potentially
functional SNPs in candidate genes is necessary, given the inconsistency of previous reported studies. This
review focuses on genetic variants that contribute to the etiology of gastric cancer, particularly those SNPs
involved in inflammatory response, metabolism of chemical carcinogens, DNA repair, and tumor suppression. In
the future, well-designed large multicenter population-based studies will be needed to validate current findings
and provide the rationale for identifying at-risk subpopulations for primary prevention of gastric cancer.
(AJTR812001).
Key Words: Gastric cancer, meta-analysis, genetic polymorphism
Full Text PDF
Address all correspondence to:
Qingyi Wei, MD, PhD
Department of Epidemiology
The University of Texas M. D. Anderson Cancer Center, Unit 1365
1515 Holcombe Blvd, Houston, TX 77030
USA
Phone: 713-792-3020; Fax: 713-563-0999;
E-mail: qwei@mdanderson.org
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