AJTR Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Am J Transl Res 2012;4(2):240-246

Original Article
Validation of transcatheter left ventricular electromechanical mapping
for assessment of cardiac function and targeted transendocardial
injection in a porcine ischemia-reperfusion model

Sharven Taghavi*, Jason M Duran*, Remus Berretta, Catherine Makarewich, Foram Udeshi, Thomas Sharp,
Hajime Kubo, Steven R Houser, Jon C George

Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA, USA. *Both authors
contributed equally

Received March 31, 2012; accepted April 15, 2012; Epub April 18, 2012; Published April 30, 2012

Abstract: Ischemic heart disease, despite advances in treatment, remains the major cause of mortality worldwide.
NOGA 3D left ventricular electromechanical mapping allows accurate determination of cardiac function and
precise identification of sites of injury. In a porcine model of ischemia-reperfusion injury, we validate the use of
the NOGA mapping system for assessment of cardiac function along with the Myostar injection catheter for
directed delivery of therapeutics to localized target sites in the setting of acute myocardial injury. (AJTR1203006).

Keywords: Directed delivery of therapeutics , heart disease,  transcatheter left ventricular electromechanical
mapping , NOGA 3D

Address all correspondence to:
Dr. Jon C. George, Adjunct Research Instructor, Cardiovascular Research Center, Temple University School of
Medicine, 3500 N. Broad Street, MERB 1040, Philadelphia, PA 19140, 215-707-4045; Director of Clinical
Research, Interventional Cardiology and Endovascular Medicine, Deborah Heart and Lung Center, 200 Trenton
Road, Browns Mills, NJ 08015, 609-735-2907 E-mail: jcgeorgemd@hotmail.com