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Am J Transl Res 2012;4(2):127-150
Review Article
Long non-coding RNAs: versatile master regulators of gene
expression and crucial players in cancer
Lei Nie, Hsing-Ju Wu, Jung-Mao Hsu, Shih-Shin Chang, Adam LaBaff, Chia-Wei Li, Yan Wang, Jennifer L Hsu,
Mien-Chie Hung
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515
Holcombe Boulevard, Houston, TX 77030; Center for Molecular Medicine, China Medical University Hospital,
Taichung, Taiwan; Graduate Institute of Cancer Biology, College of Medicine, China Medical University, Taichung,
Taiwan; Asia University, Taichung, Taiwan
Received February 3, 2012; accepted February 16, 2012; Epub April 8, 2012; Published April 30, 2012
Abstract: With rapid development of sequencing technologies such as deep sequencing and whole genome
high-density tiling array, we now know that most of the “junk” genomic sequences are transcribed as non-coding
RNAs (ncRNAs). A large number of long ncRNA transcripts (> 200bp) have been identified, and these long
ncRNAs (LncRNAs) are found to be crucial regulators for epigenetic modulation, transcription, and translation. In
this review, we briefly summarize the regulatory function of LncRNAs with a particular focusing on the underlying
mechanisms of LncRNAs in oncogenesis, metastasis and tumor suppression. (AJTR1202001)
Keywords: Long Non-coding RNA (LncRNA), epigenetic regulation, competitive endogenous RNA (ceRNA),
oncogenic lncRNA, pseudogene transcript, natural antisense rnA (NAT)
Address all correspondence to:
Dr. Mien-Chie Hung,
Department of Molecular and Cellular Oncology, Unit 108
The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd., Houston, TX 77030, USA
Tel: 713-792-3668; Fax: 713-794-3270
E-mail: mhung@mdanderson.org
Review Article
Long non-coding RNAs: versatile master regulators of gene
expression and crucial players in cancer
Lei Nie, Hsing-Ju Wu, Jung-Mao Hsu, Shih-Shin Chang, Adam LaBaff, Chia-Wei Li, Yan Wang, Jennifer L Hsu,
Mien-Chie Hung
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515
Holcombe Boulevard, Houston, TX 77030; Center for Molecular Medicine, China Medical University Hospital,
Taichung, Taiwan; Graduate Institute of Cancer Biology, College of Medicine, China Medical University, Taichung,
Taiwan; Asia University, Taichung, Taiwan
Received February 3, 2012; accepted February 16, 2012; Epub April 8, 2012; Published April 30, 2012
Abstract: With rapid development of sequencing technologies such as deep sequencing and whole genome
high-density tiling array, we now know that most of the “junk” genomic sequences are transcribed as non-coding
RNAs (ncRNAs). A large number of long ncRNA transcripts (> 200bp) have been identified, and these long
ncRNAs (LncRNAs) are found to be crucial regulators for epigenetic modulation, transcription, and translation. In
this review, we briefly summarize the regulatory function of LncRNAs with a particular focusing on the underlying
mechanisms of LncRNAs in oncogenesis, metastasis and tumor suppression. (AJTR1202001)
Keywords: Long Non-coding RNA (LncRNA), epigenetic regulation, competitive endogenous RNA (ceRNA),
oncogenic lncRNA, pseudogene transcript, natural antisense rnA (NAT)
Address all correspondence to:
Dr. Mien-Chie Hung,
Department of Molecular and Cellular Oncology, Unit 108
The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd., Houston, TX 77030, USA
Tel: 713-792-3668; Fax: 713-794-3270
E-mail: mhung@mdanderson.org
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