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Am J Translational Res 2011;3(4):383-391
Review Article
A systemic review of pet and biology in lung cancer
Kyoichi Kaira, Noboru Oriuchi, Noriaki Sunaga, Tamotsu Ishizuka, Kimihiro Shimizu, Nobuyuki Yamamoto
Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho, Sunto-gun,
Shizuoka, 411-8777, Japan; Department of Medicine and Molecular Science and Department of Thoracic and
Visceral Surgery, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma 371-8511,
Japan.
Received June 29, 2011; Accepted July 22, 2011; Epub July 27, 2011; Published August 15, 2011
Abstract: Positron emission tomography imaging with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG) has
been established as a significant molecular imaging technique in the management of lung cancer. However,
18F-FDG accumulation is not specific, therefore several other radiotracers targeting hypoxia, cell proliferation and
amino acid metabolism have been developed for the imaging of human cancers. This review summarizes the
current data on the correlation between the underlying molecular biology and tumor PET accumulation in lung
cancer. (AJTR1106006).
Keywords: Molecular biology, 18F-FDG, PET, lung cancer, molecular imaging, hypoxia, cell metabolism,
proliferation
Full Text PDF
Address all correspondence to:
Dr. Kyoichi Kaira
Division of Thoracic Oncology, Shizuoka Cancer Center
1007 Shimonagakubo Nagaizumi-cho Sunto-gun
Shizuoka, 411-8777, Japan.
Tel:+81 55 989 5222; Fax:+81 55 989 5634
E-mail: kkaira1970@yahoo.co.jp
Review Article
A systemic review of pet and biology in lung cancer
Kyoichi Kaira, Noboru Oriuchi, Noriaki Sunaga, Tamotsu Ishizuka, Kimihiro Shimizu, Nobuyuki Yamamoto
Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho, Sunto-gun,
Shizuoka, 411-8777, Japan; Department of Medicine and Molecular Science and Department of Thoracic and
Visceral Surgery, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma 371-8511,
Japan.
Received June 29, 2011; Accepted July 22, 2011; Epub July 27, 2011; Published August 15, 2011
Abstract: Positron emission tomography imaging with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG) has
been established as a significant molecular imaging technique in the management of lung cancer. However,
18F-FDG accumulation is not specific, therefore several other radiotracers targeting hypoxia, cell proliferation and
amino acid metabolism have been developed for the imaging of human cancers. This review summarizes the
current data on the correlation between the underlying molecular biology and tumor PET accumulation in lung
cancer. (AJTR1106006).
Keywords: Molecular biology, 18F-FDG, PET, lung cancer, molecular imaging, hypoxia, cell metabolism,
proliferation
Full Text PDF
Address all correspondence to:
Dr. Kyoichi Kaira
Division of Thoracic Oncology, Shizuoka Cancer Center
1007 Shimonagakubo Nagaizumi-cho Sunto-gun
Shizuoka, 411-8777, Japan.
Tel:+81 55 989 5222; Fax:+81 55 989 5634
E-mail: kkaira1970@yahoo.co.jp
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