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Am J Translational Res 2011;3(2):219-225
Original Article
Evaluation of a novel supplement to reduce blood glucose through
the use of a modified oral glucose tolerance test
Adam J. Smith, Brian Giunta, R. Douglas Shytle, James M. Blum
Life Science Solutions, LLC, West Palm Beach, FL; Center of Excellence for Aging and Brain Repair, Department
of Neurosurgery, College of Medicine, University of South Florida, Tampa, FL; Neuroimmunology Laboratory,
Department of Psychiatry and Neurosciences, College of Medicine, University of South Florida, Tampa, FL;
Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL, USA.
Received February 9, 2011; Accepted February 15, 2011; Epub February 16, 2011; Published February 28, 2011
Abstract: Elevated blood glucose is a major component in metabolic syndrome and pre-diabetes, sometimes
leading to type 2 diabetes mellitus (DM II). Additionally, it may lead to adipose deposits when left elevated for long
periods. The epidemiology of DM II clearly shows that uncontrolled blood glucose levels leads to many adverse
conditions including heart disease, retinal damage, renal failure, erectile dysfunction, and other significant
medical conditions. Here we conducted a single-center, prospective, randomized, double-blinded,
placebo-controlled, parallel-group- clinical trial of a nutraceutical supplement vs. placebo to measure its glucose
lowering effect in generally healthy adults before and after a simple sugars meal. Subjects reported to the test
clinic on multiple days to receive placebo or treatment, a simple sugars meal, as well as pre-and postprandial
blood glucose measurement (modified oral glucose tolerance test). Each subject served as his or her own
control and thirty-one subjects completed the trial with at least one oral glucose tolerance test (OGTT) with the
nutraceutical supplement and placebo. Statistical analysis revealed the nutraceutical supplement significantly
lowered postprandial glucose levels by 36% and 59% at 45 and 60 minutes, respectively (***P<.001). The study
was limited by its composition of primarily overweight females. Future studies will be required over longer
periods in more heterogeneous and larger groups to determine the long-term effect of this supplement on blood
glucose levels in terms of prophylaxis or treatment for DM II. (AJTR1102001).
Keywords: Glucose tolerance test, nutraceutical supplement, diet, hyperglycemia, diabetes mellitus II, insulin
resistance
Full Text PDF
Address all correspondence to:
Dr. James Blum
Life Science Solutions, LLC
West Palm Beach, FL, USA.
Tel: (207) 299-5411
E-mail: Jblum245@aol.com
Original Article
Evaluation of a novel supplement to reduce blood glucose through
the use of a modified oral glucose tolerance test
Adam J. Smith, Brian Giunta, R. Douglas Shytle, James M. Blum
Life Science Solutions, LLC, West Palm Beach, FL; Center of Excellence for Aging and Brain Repair, Department
of Neurosurgery, College of Medicine, University of South Florida, Tampa, FL; Neuroimmunology Laboratory,
Department of Psychiatry and Neurosciences, College of Medicine, University of South Florida, Tampa, FL;
Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL, USA.
Received February 9, 2011; Accepted February 15, 2011; Epub February 16, 2011; Published February 28, 2011
Abstract: Elevated blood glucose is a major component in metabolic syndrome and pre-diabetes, sometimes
leading to type 2 diabetes mellitus (DM II). Additionally, it may lead to adipose deposits when left elevated for long
periods. The epidemiology of DM II clearly shows that uncontrolled blood glucose levels leads to many adverse
conditions including heart disease, retinal damage, renal failure, erectile dysfunction, and other significant
medical conditions. Here we conducted a single-center, prospective, randomized, double-blinded,
placebo-controlled, parallel-group- clinical trial of a nutraceutical supplement vs. placebo to measure its glucose
lowering effect in generally healthy adults before and after a simple sugars meal. Subjects reported to the test
clinic on multiple days to receive placebo or treatment, a simple sugars meal, as well as pre-and postprandial
blood glucose measurement (modified oral glucose tolerance test). Each subject served as his or her own
control and thirty-one subjects completed the trial with at least one oral glucose tolerance test (OGTT) with the
nutraceutical supplement and placebo. Statistical analysis revealed the nutraceutical supplement significantly
lowered postprandial glucose levels by 36% and 59% at 45 and 60 minutes, respectively (***P<.001). The study
was limited by its composition of primarily overweight females. Future studies will be required over longer
periods in more heterogeneous and larger groups to determine the long-term effect of this supplement on blood
glucose levels in terms of prophylaxis or treatment for DM II. (AJTR1102001).
Keywords: Glucose tolerance test, nutraceutical supplement, diet, hyperglycemia, diabetes mellitus II, insulin
resistance
Full Text PDF
Address all correspondence to:
Dr. James Blum
Life Science Solutions, LLC
West Palm Beach, FL, USA.
Tel: (207) 299-5411
E-mail: Jblum245@aol.com
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